Fig. 8.

Crystal structure of nectin-1 in complex with HSV-1 gD (3U82) and nectin-4 with MV-H (4GJT). a A ribbon representation of nectin-1/gD complex structure (nectin-1 in grey and gD in cyan) showing the interacting residues of nectin-1 that are distributed through out the front sheet (C, C′, C″, F, and G strands); most of them are identical to the residues required for nectin-1 homodimerization. b Ribbon representation of nectin-4 IgV/MV-H complex structure (nectin-4 in grey and MV-H in cyan) showing the interacting residues of nectin-4 that are localized in C′–C″, B–C and F–G loops, which are distinct from the residues involved in the homodimerization of nectin-4