Table 1.
Interacting partners of nectin/necl proteins and their functions
| Proteins | Heterophilic partner | Function |
|---|---|---|
| Members of nectin family | ||
| Nectin-1 | Nectin-3, Nectin-4, Necl-1 | Cell adhesion |
| CD96 | Immune modulation | |
| Nectin-2 | Nectin-3 | Cell adhesion |
| CD226, TIGIT | Immune modulation | |
| Nectin-3 | Nectin-1, Nectin-2, Necl-1, 2, 5 | Cell adhesion |
| TIGIT | Immune modulation | |
| Nectin-4 | Nectin-1 | Cell adhesion |
| Members of necl family | ||
| Necl-1 | Nectin-1, Nectin-3, Necl-2, 3, 4 | Cell adhesion |
| Necl-2 | Nectin-3, Necl-1, Necl-3 | Cell adhesion |
| CRTAM | Immune modulation | |
| Necl-3 | Necl-1, Necl-2 | Cell adhesion |
| Necl-4a | Necl-1 | Cell adhesion |
| Necl-5a | Nectin-3 | Cell adhesion |
| CD96, CD226, TIGIT | Immune modulation | |
| Members of extended nectin/necl family | ||
| CD96a | Nectin-1, Necl-5 | Immune modulation |
| CD226a | Nectin-2, Necl-5 | Immune modulation |
| TIGIT | Nectin-2, Nectin-3, Necl-5 | Immune modulation |
| CRTAMa | Necl-2 | Immune modulation |
| CD200a | ? | ? |
?, unknown
arepresent members are not involved in homophilic interactions