Fig. 1.

Interactions of transcriptional activators with Mediator complex. Organization of the yeast and metazoan Mediator complexes is adapted from reference [8]. Abf1 and Rap1 in yeast may interact directly or indirectly with middle or head module subunits, as indicated by the dotted line. Interactions of activators with subunits from metazoan Mediator are mostly derived from studies on mammalian Mediator, but also include some from C. elegans and A. thaliana. See text for more details