Fig. 2.

Interactions of Mediator with other co-activator complexes. a In Saccharomyces cerevisiae, activators make direct contacts to recruit both SAGA and Mediator, which may be independent or interdependent in associating with a particular promoter depending on both the activator and the promoter (dotted double arrow). Swi/Snf and Pol II recruitment generally depends on Mediator, with some possible exceptions. b In mammalian cells, Mediator participates in recruitment of a wide range of co-activators; see text for details. For clarity, interactions not involving Mediator are omitted