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Genetic manipulation of the TCR, showing two different methods of genetic manipulation of the therapeutic cell: recombinant T-cell receptor (rTCR) transference and chimeric antigen receptors (CAR) cloning (a). This new genetic engineering methodology consists on the redirection of the T cell antigenic specificity by the introduction of CARs using viral vectors (b) or TCR genes (variable α- and β-chains) (c)
