Table 2.

The role of MRAPs on MCRs cell surface expression and signaling capacity

	MRAP1		MRAP2
	Cell surface expression	Cell signaling	Cell surface expression	Cell signaling
MC1R	= [48, 55]	= [48]	= [48]	= [48]
MC2R	↑ [48, 51–55]	↑ [48, 51–55]	↑ [48, 52, 54]	↑ [48, 52, 54]
MC3R	= [48, 55]	= [48]	= [48]	↓ [48] ↑ [59]
MC4R	↓ [48, 54] = [55]	↓ [48] = [54]	↓ [48, 54]	↓ [48] = [54] ↑ [59]
MC5R	↓ [48, 51, 55]	↓ [48]	↓ [48, 51]	↓ [48]