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Schematic depiction of production of mice using iPS cells and tetraploid complementation. Retrovirus-mediated transfection with four transcription factors (Oct4, Sox2, Klf4, and c-Myc) into mouse embryonic fibroblasts (MEF) has resulted in the generation of induced pluripotent stem (iPS) cells. Then iPS cells are injected into tetraploid blastocysts to generate iPSC mice
