Table 1.
Vascular protein as detected in AH of POAG pateints by antibody microarray (data from Saccà et al. [206])
| Protein | Role | Target |
|---|---|---|
| ELAM1 | Inflammatory responses | Endothelium and cytoskeleton |
| Apo B | Inflammatory responses | Endothelium |
| Apo E | Oxidative stress response | Endothelium |
| VASP | Cell adhesion and motility | Endothelium |
| Hsp60 | Mitochondrial chaperonin | Endothelium |
| Hsp70 | Immunoreactivity | Cytoskeleton |
| Myogenin | Muscle growth and regeneration | Cytoskeleton |
| Myogenic factor 3 | Regulator of skeletal myogenesis | Cytoskeleton |
| Myotrophin | Myofibrillar growth pattern | Cytoskeleton |
| Ankyrin | Anchors cytoskeletal components | Cytoskeleton |
| Phospholipase C | PKC activator | Cytoskeleton |
| Ubiquitin | Regulation of endothelial NOS activity | Endothelium |
The presence of these proteins in AH indicates that POAG course damages the trabecular meshwork and in particular its endothelial and cytoskeletal components thus altering both TM functionality and motility