Table 1.

Selected conditions and stimuli associated with changes in the expression of EAAT3/EAAC1

Condition/stimuli	SLC1A1/Slc1a1 mRNA	EAAT3/EAAC1	Models	References
Alzheimer dementia	ND	↑	Mouse (Abeta PP23) hippocampus	[108]
	ND	↓	Mouse (3×Tg-Alzheimer’s disease) hippocampus	[109]
Dicarboxylic aminoaciduria	ND	↓	Canine kidney cell line	[12]
Epilepsy (kainate-induced convulsions)	↓	↓	Rat hippocampus	[143]
Epilepsy (methylazoxymethanol)	↓	↓	Rat hippocampal neurons	[144]
Epilepsy (pilocarpine-induced, temporal lobe epilepsy, TLE)	↑	↑	Human hippocampus	[138]
	↑	↑	Rat hippocampal neurons	[139]
	↑	↑	Rat hippocampal granule cells	[140]
	↓	↓	Human neocortical tissues	[148]
Exercise	↑	ND	Rat hippocampus in vivo	[99]
Experimental autoimmune encephalomyelitis (EAE)	↑	↑	Rat spinal cord	[132]
G–CSF	ND	↑	Rat spinal cord	[130]
HDAC inhibitors (valproic acid, trichostatin A)	↑	↑	Human oligodendroglioma Hs683 cells	[79]
Hypertonic stress	↑	↑	Bovine renal epithelial NBL-1 cells	[85, 88]
Hypoxia (pure)	↑	↑	Rat pheochromocytoma PC-12 cells	[123]
Ischemia/hypoxia	ND	↓	Piglet striatum	[112]
	↓	↓	Gerbil hippocampus	[113]
	↓	↓	Gerbil hippocampus	[114]
	↓	ND	Rat hippocampus and cerebral cortex	[119]
	ND	↓	Rat neurons and oligodendrocytes	[120]
	ND	↑	Rabbit spinal cord	[122]
Ischemic preconditioning (oxygen-glucose deprivation)	↑	↑	Rat cortical neurons in culture	[124]
	↑	↑	Rat brain in vivo	[125]
NrF2	↑	↑	Rat brain neurons in situ and in vitro	[95]
Retinoids (all-trans retinoic acid and Am80, a synthetic retinoid)	↑	↑	Rat glioma C6 cells	[82, 83]
RFX1	ND	↑	Rat glioma C6 cells; rat brain neurons in situ	[91]
Schizophrenia	↑	↑	Human cortex	[154]
	↑	↑	Human frontal cortex	[155]
	↓	ND	Human striatum	[157]
Tunicamycin (ER stress?)	↑	↑	Bovine renal epithelial NBL-1 cells	[88]

ND not determined