Table 1.
Expression pattern and biological functions of Sox4 in different types of malignancies and its correlation with patient survival
| Type of tumor | Sox4 expression | Method of detection | Suggested function | Correlation with survival | Reference |
|---|---|---|---|---|---|
| Acute myeloid leukemia | ↑ | Western blot | Promotion of cell growth | ND | [96] |
| Adenoid cystic carcinoma | ↑ | cDNA microarray | ND | ND | [82] |
| Adenoid cystic carcinoma | ↑ | Tissue microarray | Suppression of apoptosis | ND | [81] |
| Bladder carcinoma | ↑ | cDNA microarray/tissue microarray | Induction of apoptosis | Positive | [75] |
| Colon adenocarcinomas | ↓ | cDNA microarray | ND | ND | [131] |
| Colorectal cancer | ↑ | Tissue microarray | ND | ND | [112] |
| Colorectal cancer | ↑ | cDNA microarray | ND | Negative | [112] |
| Cutaneous melanoma | ↓ | Tissue microarray | Suppression of invasion and migration | Positive | [104] |
| Endometrial cancer | ↑ | Tissue microarray | Promotion of cell growth | ND | [85] |
| Hepatocellular carcinoma | ↑ | Tissue microarray | Suppression of apoptosis | Positive | [77] |
| Gallbladder carcinoma | ↓ | IHC | ND | Positive | [110] |
| Gastric cancer | ↑ | Tissue microarray | Suppression of apoptosis | Negative | [86] |
| Glioblastoma | ↑ | Parallel signature sequencing/RT-PCR/IHC | ND | ND | [99] |
| Lung cancer | ↑ | RT-PCR/western blot | Induce transformation of NIH3T3 cells | ND | [76] |
| Medulloblastoma | ↑ | RT-PCR/ISH | ND | ND | [65] |
| Medulloblastoma | ↑ | RT-PCR | ND | ND | [132] |
| Pediatric medulloblastoma | ↑ | cDNA microarray | ND | Positive | [111] |
| Prostate cancer | ↑ | cDNA microarray | ND | ND | [78] |
| Prostate cancer | ↑ | Tissue microarray/cDNA microarray | Suppression of apoptosis | ND | [79] |
| Uveal melanoma | ↓ | Suppressive subtractive hybridization | ND | ND | [105] |
ND not determined, ISH in situ hybridization, IHC immunohistochemistry