Table 2.

Validated direct transcriptional targets of Sox4

Tissue/cell type	Gene symbol	Mode of regulation	Function	Assay	References
Breast cancer	ZEB1	↑	Transcription repressor	Reporter assay	[89]
Breast cancer	Snail	↑	Transcription repressor	Reporter assay	[89]
Colon carcinoma	p56lck	↑	Protein tyrosine kinase	Reporter assay	[67]
COS1	Tubb3	↑	β-tubulin isotype III	EMSA	[34]
Endometrial carcinomas	TCF4	↑	Transcription factor	Reporter assay	[53]
Glioma	Sox2	↑	Transcription factor	ChIP	[51]
HCC	SLC2A1	↑	Agmatine transport	ChIP	[90]
HCC	Bax	↓	Apoptosis	ChIP	[77]
HCC	CREB3L1	↑	Axon guidance	ChIP	[90]
HCC	MYEF2	↑	Axon guidance	ChIP	[90]
HCC	NAV3	↑	Axon guidance	ChIP	[90]
HCC	NRP1	↑	Axon guidance	ChIP	[90]
HCC	SEMA3C	↑	Axon guidance	ChIP	[90]
HCC	NEIL3	↑	Base excision DNA repair	ChIP	[90]
HCC	CHFR	↑	Cell cycle checkpoints	ChIP	[90]
HCC	NPNT	↑	Extracellular matrix protein	ChIP	[90]
HCC	GPRC5B	↑	G-protein signaling pathway	ChIP	[90]
HCC	HUNK	↑	Kinase	ChIP	[90]
HCC	PFKFB4	↑	Kinase	ChIP	[90]
HCC	AKR1B10	↑	Metabolism	ChIP	[90]
HCC	ALDH18A1	↓	Metabolism	ChIP	[90]
HCC	DHRS13	↑	Metabolism	ChIP	[90]
HCC	GYG	↑	Metabolism	ChIP	[90]
HCC	PAM	↑	Metabolism	ChIP	[90]
HCC	RCC2	↓	Metabolism	ChIP	[90]
HCC	MAP4	↑	Microtubule-associated protein	ChIP	[90]
HCC	SMG5	↑	mRNA decay	ChIP	[90]
HCC	HSPBAP1	↓	Protein folding	ChIP	[90]
HCC	LCK	↑	Protein tyrosine kinase	ChIP	[90]
HCC	CSPG2	↑	Proteoglycan	ChIP	[90]
HCC	CTSC	↑	Proteolysis	ChIP	[90]
HCC	RBM10	↓	RNA binding	ChIP	[90]
HCC	SERPINE2	↑	Serine protease inhibitor	ChIP	[90]
HCC	INST8	↑	Small nuclear RNAs processing	ChIP	[90]
HCC	HIC2	↓	Transcription factor	ChIP	[90]
HCC	VGLL4	↑	Transcription factor	ChIP	[90]
HCC	FOXQ1	↑	Transcription factor	ChIP	[90]
HCC	TEAD2	↑	Transcription factor	ChIP	[90]
HCC	CCDC97	↓	Unknown	ChIP	[90]
HCC	UBAP2L	↓	Unknown	ChIP	[90]
HCC	DKK1	↑	Wnt signaling pathway	ChIP	[90]
Heart	Connexin 43	↑	Gap junction protein	ChIP	[27]
Hemangioblasts	λ5	↑	Component of precursor of BCR	ChIP	[31]
Hemangioblasts	VpreB1	↑	Component of precursor of BCR	ChIP	[31]
Melanoma	NF-κB p50	↓	Inflamation, cell growth	ChIP	[104]
Melanoma	Dicer	↑	miRNA biogenesis	ChIP	[107]
Mouse embryonic mesenchymal cells	Tead2	↑	Transcription factor	ChIP	[25]
Myeloid Leukemia	CREB	↑	Transcription factor	ChIP	[96]
Myeloid leukemias	Sfpi1	↓	Transcription factor	ChIP	[93]
Myeloma	CD56	↑	Immunoglobulin superfamily	ChIP	[97]
Neural cells	DCX	↑	Microtubule-associated protein	ChIP	[35]
Neural cells	GnRH	↑	Sexual development	ChIP	[133]
Neural cells	FEZF2	↑	Transcription factor	ChIP	[36]
Prostate	PUMA	↑	Apoptosis	ChIP	[79]
Prostate	MLL	↑	Histone methyl-transferase	ChIP	[80]
Prostate	ADAM10	↑	Metalloproteinase	ChIP	[80]
Prostate	AGO1	↑	miRNA biogenesis	ChIP	[80]
Prostate	DHX9	↑	miRNA biogenesis	ChIP	[55, 80]
Prostate	Dicer	↑	miRNA biogenesis	ChIP	[55, 80]
Prostate	DLL1	↑	Notch signaling	ChIP	[80]
Prostate	HES2	↑	Notch signaling	ChIP	[80]
Prostate	RBL1	↑	Regulation of cell cycle	ChIP	[80]
Prostate	EGFR	↑	Signaling	ChIP	[80]
Prostate	ELF5	↓	Transcription factor	ChIP	[80]
Prostate	Sox4	↑	Transcription factor	ChIP	[55]
Prostate	ZNF281	↑	Transcription repressor	ChIP	[80]
Prostate	TLE-1	↑	Transcription repressor	ChIP	[79, 80]
Prostate	FZD3	↑	Wnt receptor	ChIP	[80]
Prostate	FZD5	↑	Wnt receptor	ChIP	[80]
Prostate	FZD8	↑	Wnt receptor	ChIP	[80]
Prostate	AXIN2	↑	Wnt signaling	ChIP	[55]
SCLC	VASH2	↑	Angiogenic factor	ChIP	[83]
SCLC	PCDHB	↑	Protocadherin	ChIP	[83]
SCLC	Tead2	↑	Transcription factor	ChIP	[83]
SCLC	MYB	↑	Transcription factor	ChIP	[83]
SCLC	Tubb3	↑	β-tubulin isotype III	ChIP	[83]
T-cells	Interleukin 5	↓	Cytokine	ChIP	[32]
T-Cells	CD2	↑	Surface antigen	EMSA	[134]

EMSA electrophoretic mobility shift assay, ChIP chromatin immunoprecipitation, HCC hepatocellular carcinoma