Fig. 5.

MTOC-dependent centrosome-organelle/structure interactions. a MTOCs are formed on the organelle and nucleate microtubules (i). Microtubules nucleated from the organelle MTOC and the centrosome elongate and shorten repeatedly (black arrows). After the organelle-centrosome connection is established by interaction of the microtubules (ii), the organelle and the centrosome are brought into close proximity via the connecting microtubules [iii and iv, magenta arrows]. b Comparison of various centrosome-organelle/structure interactions is shown. NE nuclear envelope, H human, Y budding yeast, M mouse, W worm, F fly