Table 1.

Summary of the biological processes, molecular functions, and cellular components, which were annotated based on Gene Ontology (GO), across the four domains of life

annotation	types of annotations	in Archaea	in Bacteria	in Eukaryota	in Viruses
biological processes	total # of processes	12	318	104	2
	# of processes with significant depletion in disorder	0	76	31	0
	# of processes with significant enrichment in disorder	1	14	10	1
molecular functions	total # of functions	34	581	161	4
	# of functions with significant depletion in disorder	1	184	63	0
	# of functions with significant enrichment in disorder	2	20	6	1
cellular components	total # of components	6	61	50	5
	# of components with significant depletion in disorder	0	12	6	0
	# of components with significant enrichment in disorder	1	13	3	2

The numbers in bold indicate the total number of significant sub-functions in a given domain of life that are used to investigate potential depletion or enrichment of the disorder