Fig. 1.

Multiple sequence alignment and three-dimensional structures of sarafotoxin and endothelin peptides. Conserved cysteines are shown in bold in the sequence alignment. Accession numbers are as follows: P05305, P20800, P14138, P23943, P13208, Q6RY98. A The NMR structure of SRTX-b from Atractaspis engaddensis (1SRB) showing the Ser2 residue important for vasoconstriction activity. B The NMR structure of human endothelin-1 (1V6R) showing Asp8, Glu10 and Phe14 important for biological activity. Functional residues are highlighted in red and disulfide bridges are depicted in yellow