Fig. 7.

Multiple sequence alignment and three-dimensional structures of disintegrins. Alignment of snake venom long disintegrins (Bilitoxin-1, Salmosin3), medium disintegrins (Trigramin, Barbourin), dimeric disintegrins (Contortrostatin, EC3A, EC3B) and small disintegrins (Echistatin, Obtustatin) using CLC Main Workbench 6. Highly conserved residues are highlighted in purple while semi-conserved residues are a lighter purple. Sequence logo is shown below the alignment. Ribbon models A and B represent small disintegrins Echistatin (1RO3) and Obtustatin (1MPZ), respectively. Functional tripeptides are highlighted in red (Echistatin-RGD; Obtustatin-KTS) and disulfide bridges are highlighted in yellow