Fig. 8.

Multiple sequence alignment and three-dimensional structures of snake and mammalian PLA₂s. Alignment of snake venom Group IA PLA₂ (Notexin, Pa-11); Group IB PLA₂ (OHV-PLA2); Group II PLA₂ (Crotoxin basic chain, B. asper D49, B. asper K49) and mammalian sPLA₂ (Human Group IIA, Human Group V) using CLC Main Workbench 6. Highly conserved residues are highlighted in red while semi-conserved residues are a lighter red. Sequence logo is shown below the alignment. Toxin nomenclature is based on Uniprot. Ribbon models are A Group IA Notexin (1AE7), red residues-H48, D49, teal residues-Y75, Y76, Y83, pink square-elapid loop; B Group IB OHV-PLA₂ (1GP7), red residues-H48, D49, pink square-pancreatic loop; C Group II RVV-VD (1VIP), red residues-H48, D49; D Group II Piratoxin-II (1QLL), red residues-H48, K49. Both ribbon models C and D show the extended C-terminus in blue