Table 1.
Leukemia/lymphoma-associated gene fusions in healthy individuals
| Translocation | Assay system | Cells | Frequency | Reference |
|---|---|---|---|---|
| t(9;22) | Nested RT-PCR | Peripheral blood leukocytes |
p190 BCR/ABL 11/16 (69 %) p210 BCR/ABL 4/15 (27 %) |
Bose et al. [48] |
| Nested RT-PCR | Peripheral blood leukocytes | 23/117 (19.7 %) | Biernaux et al. [47] | |
| t(2;5) | RT-PCR, Southern hybridization | Peripheral blood leukocytes | 14/29 (48.3 %) | Trumper et al. [49] |
| Real-time PCR | Lymph nodes and spleen | 20/31 (64.5 %) | Maes et al. [50] | |
| t(11;14) | Real-time qPCR | Peripheral blood leukocytes | 1/100 (1 %) | Hirt et al. [51] |
| t(14;18) | Nested PCR | Peripheral blood leukocytes | 19/230 (8.3 %) | Paltiel et al. [102] |
| Nested PCR | Peripheral blood mononuclear cells | 40/254 (15.7 %) | Zignego et al. [71] | |
| Nested PCR | Peripheral blood leukocytes | 31/55 (56.4 %) | Henriksson et al. [103] | |
| Nested qPCR | Peripheral blood mononuclear cells | 10/23 (43.5 %) | Scheerer et al. [104] | |
| Semi nested PCR |
Bone marrow aspirates Peripheral blood lymphocytes |
89/224 (39.7 %) | Rauzy et al. [105] | |
| Nested qPCR | Peripheral blood mononuclear cells, umbilical cord cells | 69/127 (54.3 %) | Liu et al. [106] | |
| Seminested qPCR | Peripheral blood mononuclear cells | 26/57 (45.6 %) | Dolken et al. [56] | |
| Nested qPCR | Peripheral blood leukocytes | 30/34 (88.2 %) | Fuscoe et al. [57] | |
| PCR Southern blot/seminested PCR | Lymph node tissue | 19/48 (39.6 %) | Molina et al. [107] | |
| Nested qPCR | Peripheral blood mononuclear cells | 25/64 (39.1 %) | Cole et al. [108] | |
| Seminested PCR | Peripheral blood mononuclear cells, granulocytes, lymphocytes | 6/9 (66.7 %) | Limpens et al. [58] | |
| Seminested qPCR, P32-labelling | Peripheral blood mononuclear cells | 70/146 (47.9 %) | Ji et al. [68] | |
| Nested qPCR | Peripheral blood leukocytes | 57/122 (46.7 %) | Bell et al. [69] | |
| PCR | Lymph nodes | 18/108 (16.6 %) | Corbally et al. [109] | |
| Nested qPCR | Peripheral blood lymphocytes | 40/84 (47.6 %) | Liu et al. [55] | |
| Seminested PCR and Southern blot | Lymphoid tissue | 10/25 (40 %) | Aster et al. [62] | |
| PCR and Southern blot | Lymph nodes and tonsils | 13/73 (17.8 %) | Limpens et al. [110] | |
| Real-time qPCR | Peripheral blood mononuclear cells | 287/644 (45 %) | Dolken et al. [67] | |
| Nested PCR, real-time PCR | Peripheral blood mononuclear cells | 16/125 (12.8 %) | Ladetto et al. [111] |