Table 1.
List of FXR coactivators, their functions and the context (cell type, gene) of their association with FXR
| Coactivator | Function | Substrate | Model | Genes | Reference |
|---|---|---|---|---|---|
| P300 | Histone acetyl transferase (HAT) | H3K9/K14 | HepG2; IHH; mouse liver | SHP TXNIP | [133, 194, 227] |
| CARM1 | Arginine methyltransferase | H3R17 | HepG2 | BSEP | [191] |
| PRMT1 | Arginine methyltransferase | H4R3 | HepG2 | SHP BSEP | [190] |
| MLL3 | Lysine methyltransferase | H3K4 | HepG2; mouse liver | SHP BSEP Mrp2 | [193] |
| MLL4 | Lysine methyltransferase | H3K4 | HepG2 | SHP BSEP | [193] |
| ASC2 (NCOA6) | Recruitment of MML3/4 | HepG2; mouse liver | SHP BSEP KNG1 Mrp2 | [192, 193, 200] | |
| Brg1 | ATPase chromatin remodeler | HepG2; mouse liver | SHP | [195] | |
| TRRAP | Recruitment of HAT | HepG2 | Reporter assay with FXRE | [188] | |
| Set7/9 | Non-histone methyltransferase | FXR | Huh7 | SHP BSEP | [189] |
| SRC1 | HepG2 | Two-hybrid assay SHP BSEP OSTα | [198, 228, 229] | ||
| SRC2 | HepG2 | KNG1 | [200] | ||
| PGC1α | Recruitment of other cofactors | HepG2 | IBABP BSEP | [187] | |
| SIRT1 | Deacetylase | PGC1α, FXR | Mouse liver and intestine | Shp Ostβ | [220] |