Table 1.
Example targets for different NMD-inducing features
| NMD-inducing feature | Transcript | Accession number | Reference |
|---|---|---|---|
| PTC |
T-cell receptor β (TCRB) β-Globin (HBB) |
HGNC:12155 (TCRB)a HGNC:4827 (HBB) |
[66, 218] |
| Long 3′ UTR |
Protein SMG5 (SMG5) Regulator of nonsense transcripts 3B (UPF3b) |
HGNC:24644 (SMG5) HGNC:20439 (UPF3b) |
[5, 55] |
| Sec codon |
Glutathione peroxidase 1 (GPx1) Selenoprotein W (SelW) |
HGNC:4553 (GPx1) HGNC:10752 (SelW) |
[81, 219] |
| uORF |
Interferon-related development factor 1 (IFRD1) Mitogen-activated protein kinase kinase kinase 14 (MAP3K14) |
HGNC:5456 (IFRD1) HGNC:6853 (MAP3K14) |
[82, 220] |
| Alternative splicing |
Serine/arginine splicing factor 2 (SRSF2/SC35) Fibroblast growth factor receptor 2 (FGFR2) |
HGNC:10783 (SRSF2/SC35) HGNC:3689 (FGFR2) |
[86, 221] |
| lncRNA |
Growth arrest-specific 5 (GAS5) Small nucleolar RNA host gene 5 (SNHG5) |
HGNC:16355 (GAS5) HGNC:21026 (SNHG5) |
[87, 181] |
aAccession number will not lead to the gene sequence targeted by NMD