Table 3.
4.1B/DAL-1 methylation in tumors
| Tumor type | Number of cases/cell lines | Number of cases/cell lines with 4.1B/DAL-1 methylation (%) | References |
|---|---|---|---|
| Lung cancer | |||
| NSCLC cell lines | 39 | 17 (44) | [81, 91] |
| Adenocarcinoma | 28 | 12 (43) | |
| Squamous cell carcinoma | 5 | 3 (60) | |
| Large cell carcinoma | 6 | 2 (33) | |
| Pleural fluid NSCLC cells | 9 | 6 (67) | |
| SCLC cell lines | 11 | 3 (27) | |
| Primary lung tumors | [81, 85] | ||
| NSCLC | |||
| Adenocarcinoma | 133 | 75 (56) | |
| Squamous cell carcinoma | 109 | 60 (55) | |
| Large cell carcinoma | 8 | 4 (50) | |
| Adenosquamous cells carcinoma | 18 | 8 (44) | |
| SCLC | 4 | 0 (0) | |
| Corresponding nonmalignant lung tissue samples | 30 | 3 (10) | |
| Pleural fluid NSCLC | 103 | 59 (57) | |
| Breast cancer | |||
| Breast cancer cell lines | 8 | 6 (75) | [84] |
| Primary breast cancers | 95 | 26 (27) | |
| Ductal carcinoma | 81 | 21 (26) | |
| Lobular carcinoma | 13 | 4 (31) | |
| Other | 1 | 1 (100) | |
| Renal clear cell carcinoma | |||
| RCC cell lines | 19 | 9 (47) | [34] |
| Primary RCCC | 55 | 25 (45) | |
| Prostate cancer | |||
| Prostate carcinoma cell lines | 4 | 3 (75) | [97] |
| Primary tumor tissues | 113 | 89 (79) | |