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. 2013 Jun 15;70(23):4555–4567. doi: 10.1007/s00018-013-1394-1

Fig. 1.

Fig. 1

Cartoon showing the generic difference between the top–down, bottom–up and holistic approaches. a The withdrawal/addition of the squares indicates the gain and loss of the organisational complexity in the top–down and bottom–up approaches, respectively. b The arrow closing on itself indicates an irreducible organisational complexity (circularity) despite compositional changes (indicated by alterations of color intensity) in the holistic approach