Fig. 2.

Structure of the human MMP23 loci and the corresponding gene product [4]. Schematic representation of the ~150-kb region of chromosome 1p36.3 that contains the two metalloprotease 23 genes (mmp23a and mmp23b). The genes are represented by arrows orientated to highlight their transcriptional orientation relative to the neighboring CDK11 (cyclin-dependent kinase 11), MIB2 (mindbomb E3 ubiquitin protein ligase 2), and SLC35E2B (solute carrier family 35, member E2B) genes. The exon/intron structure and protein domain architecture for the MMP23 gene and isoforms (MMP23, MMP23a, and MMP23b) formed by alternative splicing are also illustrated. The location of exons constituting the mmp23 gene and protein (MMP23) are listed in the table