Table 2.

Posttranslational modifications of 3′SS factors

Splicing factor	Modification	Residue	Effect on splicing	References
U2AF65	Hydroxylation	Lys-15, Lys-276	Activating	[162]
SF1	Phosphorylation	Ser-80, Ser-82, Ser-20	Activating/repressing	[163–166]
hnRNP K	Phosphorylation	Ser/Thr (predicted)	Repressing	[43]
hnRNP L	Phosphorylation	Ser-513	Repressing	[46]
DEK	Phosphorylation	Ser-19, Ser-32	Activating	[64]
Sm proteins	Methylation	Arg rich motifs	Activating	[167]
SRSF2	Acetylation	Lys-52	Activating	[168, 169]
U2AF35	Ubiquitination	Within residues 43–146	Repressing	[170]
Prp3	Ubiquitination	Two Lys residues	Repressing	[171]
SF3ba	Spliceostatin binding	NA	Repressing	[172]

NA not applicable

^aNon-covalent binding