Fig. 9.

Working model of Pyk2 intracellular localization regulation. a In basal conditions, Pyk2 is phosphorylated on S778 by PKA, the NES in the linker region between the kinase and the FAT domain, is active, and Pyk2 is predominantly cytoplasmic. b After a rise of Ca²⁺, for example through opening of voltage-sensitive Ca²⁺ channels, calcineurin is activated and dephosphorylates S778 leading to the inactivation of the NES. Pyk2 then accumulates in the nucleus due to the predominant activity of the NLS and possibly the NTS