Fig. 3.
Type 1 diabetic serum increases whole-cell CaV currents in CaV1.3+/+ and CaV1.3−/− β cells. a Sample whole-cell CaV current traces from a CaV1.3+/+ β cell incubated with either healthy serum (cell capacitance: 5.9 pF) or T1D serum (cell capacitance: 5.6 pF). b Average CaV current density–voltage relationships in CaV1.3+/+ cells exposed to healthy serum (open circles, n = 36 cells) and T1D serum (filled circles, n = 36 cells), respectively. c Representative whole-cell CaV current traces from a CaV1.3−/− β cell following treatment with healthy serum (cell capacitance: 5.4 pF) and T1D serum (cell capacitance: 5.5 pF), respectively. d Average CaV current density–voltage relationships in CaV1.3−/− β cells subjected to exposure to either healthy serum (open circles, n = 35 cells) or T1D serum (filled circles, n = 35 cells). *p < 0.05 and **p < 0.01 vs. healthy serum