Fig. 1.
Longitudinal testing of PLB1Triple and PLB1WT mice in the radial arm water maze protocol in a problem-solving task aged 4, 8, and 12 months. Group mean ± SEM. No significant difference was found between transgenic and wild-type mice in (a) number of trials required to reach criterion or (b) number of errors committed before reaching criterion. Dissection of the errors committed into (c) reference and (d) working memory errors also did not yield any difference. However, swim speed (e) differed between genotypes and there was an age-related decline in swimming velocity, which was genotype-independent. *p < 0.05, n.s. not statistically significant