Fig. 3.

PSAPP mice are impaired in a problem solving task in the radial arm water maze when tested longitudinally at 4, 8 and 12 months. Reliable differences were obtained for a number of trials required to reach criterion and b number of errors committed before reaching criterion (overall genotype difference = p < 0.01 for each comparison). The deficit was due to impairments in both reference (c) and working memory errors (d) (p < 0.01 for each). Swim speed e was significantly elevated in PSAPP transgenic animals at all ages (p < 0.01 in each case) with no obvious decay over time. Group mean ± SEM. **p < 0.01 and ***p < 0.001, respectively