Fig. 4.

Memory impairment in PSAPP transgenic mice tested after achieving criterion in a problem solving task. Although both transgenic and wild-type mice presented with a statistically significant preference for the target arm at 4, 8 and 12 months of age (p < 0.01 in each case) PSAPP mice spent reliably less time in the target arm than WT mice at 4 and 12 months, but not at 8 months (p < 0.05 and p < 0.01). For each age group and genotype, probe trial sample traces are shown below the corresponding graph. Group means + SEM. *p < 0.05, **p < 0.01, and ***p < 0.001, respectively