Fig. 6.
Non-spatial parameters recorded in the open-field water maze in PLB1Triple and PLB1WT mice at 4 and 12 months, respectively. a PLB1Triple mice presented with elevated swim speed compared with wild types (p < 0.001 and p < 0.05, respectively), which decayed by age. No age-related change was found in PLB1WT. Group means over all training days ± SEM. b, c Mean daily time (±SEM) spent in the thigmotaxis zone of the pool was greater on the first day of experimentation in transgenic mice (b) at 4 months (p < 0.05), but not on any other day or at 12 months (c). *p < 0.05 and ***p < 0.001, respectively