Fig. 2.

Summary of YAP1 and TAZ regulation. The core kinase cassette, comprising MST1/2, WW45, MOB1, and LATS1/2, negatively regulates YAP1 and TAZ by phosphorylation. In the nucleus YAP1 and TAZ interact with various transcription factors. TEAD interacts with Vgll. YAP1 and TAZ are regulated by “Membrane-associated proteins and cell junction proteins”, “Cell adhesion molecules and receptors”, “Actin cytoskeleton” and “Cross-talk with other signaling pathways”. The components are summarized in Table 2. LKB1 alters the localization of Scribble. ILK inactivates Merlin. TAO-1, SIK, and RASSF regulate MST1/2 activities. NPHP4, NPHP9, and ASPP1 directly interact with TAZ or YAP1. HIPK2 and ANKHD1 modulate transcription mediated by YAP1. Cytoplasmic YAP1 and TAZ interact with 14-3-3 and several other proteins. Nuclear YAP1 and TAZ interact with several proteins including PML and MED15 along with transcription factors