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Core components of Drosophila and mammalian Hippo pathways
| Drosophila | Mammal | Brief description |
|---|---|---|
| Hpo | Mammalian Ste20-like kinases (MST1/2) | Serine/threonine kinases |
| Sav | WW45/Sav1 | Adaptor protein |
| Mats | MOB1 | Adaptor protein |
| Wts | Large tumor suppressor kinases (LATS1/2) | Serine/threonine kinases |
| Yki | Yes-associated protein (YAP1) | Transcriptional co-activator |
| Transcriptional co-activator with PDZ-binding motif (TAZ/WWTR1) |
For simplicity, only the core founding components of the pathway are listed
