Table 1.
Drosophila | Mammal | Brief description |
---|---|---|
Hpo | Mammalian Ste20-like kinases (MST1/2) | Serine/threonine kinases |
Sav | WW45/Sav1 | Adaptor protein |
Mats | MOB1 | Adaptor protein |
Wts | Large tumor suppressor kinases (LATS1/2) | Serine/threonine kinases |
Yki | Yes-associated protein (YAP1) | Transcriptional co-activator |
Transcriptional co-activator with PDZ-binding motif (TAZ/WWTR1) |
For simplicity, only the core founding components of the pathway are listed