Table 2.

Summary of studies examining microbial activation of MAIT cells in vitro

Microbe	APC type	Activation measure	MAIT cell activation?	References
M. tuberculosis	Human monocyte-derived DCs	IFN-γ	Yes	[17]
	A549 human epithelial cell line	IFN-γ/TNF	Yes	[17]
	Human large airway epithelial cells derived from tracheal brushings	IFN-γ	Yes	[17]
M. smegmatis	Human monocyte-derived DCs	IFN-γ	Yes	[17]
	A549 human epithelial cell line	IFN-γ/TNF	Yes	[9]
E. coli	Human monocyte-derived DCs	CD69 and IFN-γ	Yes	[18]
	Murine BMDCs	CD69 and CD25	Yes	[18]
	Murine fibroblasts	CD69 and CD25	Yes	[18]
	HeLa cells	CD69 and CD25	No	[25]
	Human B cell line and primary human B cells	CD69 and cytokine production	Yes	[26]
	Human monocytic cell line (THP-1)	IFN-γ	Yes	[24]
S. typhimurium	Human monocyte-derived DCs	IFN-γ	Yes	[17]
	HeLa cells	CD69 and CD25	No	[25]
	A549 human epithelial cell line	TNF	Yes	[9]
L. monocytogenes	Human monocyte-derived DCs	IFN-γ	No	[17]
P. aeruginosa	Murine BMDCs	CD69	Yes	[18]
K. pneumoniae	Murine BMDCs	CD69	Yes	[18]
L. acidophilus	Murine BMDCs	CD69	Yes	[18]
S. aureus	Murine BMDCs	CD69	Yes	[18]
	Human monocyte-derived DCs	IFN-γ	Yes	[17]
S. epidermidis	Murine BMDCs	CD69	Yes	[18]
S. cerivisiae	Murine BMDCs	CD69	Yes	[18]
C. galbrata	Murine BMDCs	CD69	Yes	[18]
C. albicans	Murine BMDCs	CD69	Yes	[18]
	A549 human epithelial cell line	IFN-γ/TNF	Yes	[9]
E. faecalis	Murine BMDCs	CD69	No	[18]
	Human monocytic cell line (THP-1)	IFN-γ	Yes	[24]
Strep group A	Murine BMDCs	CD69	No	[18]
M. abscessus	Murine BMDCs	CD69	Yes	[18]
F. tularensis LVS	Murine BMDMs	IFN-γ	Yes	[20]
M. bovis BCG	Murine BMDMs	IFN-γ	Yes	[19]
S. flexneri	HeLa cells	CD69 and CD25	Yes	[25]
S. typhi	Human B cell line	CD69 and cytokine production	Yes	[26]
L. lactis (culture supernatant)	Human B cell line	CD69	Yes	[11]
L. lactis Δ RibA or RibG (culture supernatant)	Human B cell line	CD69	No	[11]

MAIT mucosa-associated T, BMDC bone marrow-derived dendritic cells, BMDM bone marrow-derived macrophages