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T cell differentiation. Phenotypic evolution of CD4+ (a) and CD8+ (b) T cells. CMV-experienced T cytotoxic cells exhibit a different functional phenotype compared with naïve cells. Expression of different molecules such as CD45RA, CCR7, CD28, CD27, CD57 or mediators of cytotoxicity such as IFNγ, granzyme B (GzmB) or perforin
