Fig. 3.

Regulation of endothelial cell migration by guidance cues. Guidance molecules released from astrocytes (gray) or neurons (blue) can induce or abolish endothelial cell migration depending on the receptor expressed on the endothelial cell. a Attractive and repellent signaling by Semaphorins and their receptors. b Ephrin-Eph forward and reverse signaling regulates endothelial cell migration. Binding of Slit to Robo4 inhibits endothelial cell migration and helps maintaining vascular integrity. c Binding of Netrin to Unc5B or neogenin inhibits endothelial cell migration whereas binding to integrin α6β1 attracts endothelial cells