Table 2.

Lysine demethylases and their histone and non-histone substrates in humans

KDMs	Other names	Substrates and modified lysine residues
		Histones	References	Non-histone proteins	In vitro	In cells	References
LSD1	KDM1A, AOF2	H3K4me2	Shi et al. [103] and Metzger et al. [109]	p53 K370me2	Peptide Auto-rad	WB	Huang et al. [105]
				DNMT1K142me1	Peptide Auto-rad	Auto-rad	Wang et al. [141]
				E2F1 K185me1	Protein Auto-rad	Auto-rad	Kontaki and Talianidis [21]
				MYPT1K442me1	Peptide MS	Auto-rad	Cho et al. [104]
				STAT3 K140me2	Protein Auto-rad	WB	Yang et al. [106]
				MEF2DK267me2	Protein WB	IP and WB	Choi et al. [59]
				MTA1 K532me2	Protein Auto-rad	N/A	Nair et al. [60]
				ERα K266me1	N/A	WB	Zhang et al. [72]
				HSP90 K209me1, K615me1	Protein Auto-rad	N/A	Abu-Farha et al. [73]
				HIV Tat K51me1	Protein WB	WB	Sakane et al. [107]
JMJD2A	KDM4A	H3K9me2/3, H3K36me2/3	Whetstine et al. [112] and Klose et al. [113]	G9a K185me3, WIZ K305me3, CDYL1 K135me3, CSB K170me3, K297me3, K448me3, K1054me3	Peptide MS	N/A	Ponnaluri et al. [114]
FBXL11	KDM2A	H3K36me2	Tsukada et al. [115]	RelA K218me1, K221me2	N/A	WB	Lu et al. [93]
PHF2	JHDM1E	H3K9me2/1	Wen et al. [117]	ARID5BK336me2	Protein WB	IP and WB	Baba et al. [116]

Auto-rad autoradiography, IP immunoprecipitation, MS mass spectrometry, N/A not available, WB Western blotting using site-specific methylation antibodies