Fig. 2.
Possible roles of CAF-1 in signal transduction governing multi-cellular organism development, a hypothetic model. During development, specific signals, such as the Notch ligand, initiate a signaling cascade from outside of the cell, generating signals that enter the nucleus, e.g., NICD, to interact with specific transcription factors (TF), such as Su(H), recruiting CAF-1 to a specific chromatin region. In this context, CAF-1 regulates the local histone modifications (such as acetylation level) likely by interacting with specific histone modifiers such as a histone acetyltransferase (HAT) or a histone deacetylase (HDAC), which consequently result in either turning-on or shutting-down specific target genes, depending on the newly modified histone marks (active or repressive). However, it is unknown whether in this process CAF-1’s function is dependent on its histone chaperone activity