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Binding of penetratin and Tat peptide to LUVs of different lipid content
| Lipid mixture | K app (μM) | |
|---|---|---|
| Penetratin | Tat | |
| PC/PG | 9.0 ± 5.0 | 12 ± 7.5 |
| Chol/SM/PC/PG | 2.7 ± 0.5 | 10 ± 0.3 |
| Chol/SM/Cer/PC/PG | 1.7 ± 1.1 | 0.8 ± 0.2 |
PC/PG: 95/5 mol%; Chol/SM/PC/PG: 20/50/25/5 mol%; Chol/SM/Cer/PC/PG: 20/40/10/25/5. For calculation of K app, it was assumed that 50 % of the total lipids were accessible to the peptide in LUV
Chol cholesterol, Cer ceramide
