Table 1.

Phenotype of Nfe2 ^−/− mice

Tissue type	Phenotype	References
Hematopoietic	Neonatal death of 90 % of the mice due to hemorrhage, severe thrombocytopenia	[59]
	Lack of proplatelets	[60]
	Reduced colony-forming units megakaryocytes	[61]
	Severe anemia in neonates, mild anemia in surviving adults, splenomegaly, extensive reticulocytosis	[109]
	Increased sensitivity of red blood cells to phenylhydrazine treatment	[107]
	Increased serum EPO, altered erythroid precursor distribution in the spleen and bone marrow	[110]
Non-hematopoietic	Increased bone mass and bone formation	[125, 126]
	Intrauterine growth restriction, increased syncytiotrophoblast formation, impaired placental vascularization	[27, 128]