Table 4.
Validated mRNA targets of microRNAs relevant in pheochromocytoma
| microRNA | Validated targets in the adrenal | Principal function of target mRNA | Reference | Validated targets in other tissues | Principal function of target mRNA | Reference |
|---|---|---|---|---|---|---|
| miR-96 | Ezrin | Cell adhesion, migration | [70] | FOXO1 | Transcription factor | [75, 76] |
| miR-183 | Ezrin | Cell adhesion, migration | [70] |
SMAD4 Isocitrate dehydrogenase 2 |
Signaling, apoptosis Energy metabolism |
[77] [78] |
| miR-885-5p |
Caspase 3, CDK2, MCM5 |
Apoptosis Cell cycle |
[80] [81] |
|||
| miR-137 |
KDM1A, Ezh2 histone methyltransferase, neurofibromin 1 |
Gene expression regulation, Cell signaling |
[82] [83] [84] |
|||
| miR-382 | c-MYC | Cell cycle, apoptosis | [85] | |||
| miR-15a |
BCL2, MCL1 Cyclin D1 |
Apoptosis Cell cycle |
[88] | |||
| miR-16 |
BLC2, MCL1 Cyclin D1 |
Apoptosis Cell cycle |
[88] |
BCL2 B-cell CLL/lymphoma 2, CDK2 cyclin-dependent kinase 2, KDM1A histone demethylase, lysine-specific demethylase 1, MCL1 myeloid cell leukemia 1, MCM5 mini-chromosome maintenance complex component 5