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Three tightly interconnected pathways: infection, host innate immune response and host DDR. Cytosolic dsDNA produced after DNA damage is recognized by cytosolic PRRs which are linked to the innate immune system. When localized in the cytoplasm, Mre11, Rad50 and DNA-PK have been shown to bind dsDNA, which induces an innate immune response through several signaling pathways involving PRRs
