TABLE 2.
Multivariable models for the prediction of TTR by morphologic features and clinicopathological variables in initial cohort [p-MMR (n = 189) or d-MMR (n = 191) stage III colon cancers]
| Variable | Categorization | HR (95% CI) | P-valuea |
|---|---|---|---|
| p-MMR tumors (52 events/189 cases) | |||
| Nodes | N1 N2 |
Ref 3.14 (1.71–5.77) |
0.001 |
| T Stage | T1 or T2 T3 T4 |
b
Ref 2.56 (1.27–5.26) |
0.003 |
| Age | Continuous (5 years) | 1.13 (1.003–1.27) | 0.042 |
| Tumor-stroma ratio | Q1 Q2–4 |
2.02 (1.14–3.57) Ref |
0.018 |
| d-MMR tumors (47 events/191 cases) | |||
| Nodes | N1 N2 |
Ref 3.81 (2.06–7.06) |
<0.001 |
| Inflammatory stroma | Continuous | 0.98 (0.96–0.99) | 0.028 |
aGlobal likelihood ratio P-value.
bNot estimable due to no events in the “T1 or T2” level.