Fig. 11.

Disorder propensity and structural features of the HIV-1 protease. a Crystal structure of the PR dimer (3KF1). b Crystal structure of the protease monomer (3HVP). c NMR solution structure of 1–95 fragment of the HIV-1 PR (1Q9P). Ten representative members of the conformational ensemble are shown by ribbons of different color. d Disorder prediction evaluated by PONDR^® VSL2 (top panel) and PONDR^® VLXT (bottom panel). Red line represents an averaged disorder score for PR from ~50 different HIV-1 isolates. Pink shadow covers the distribution of disorder scores calculated for PR from these isolates. Locations of β-strands and α-helices seen in the crystal structure are indicated by gray and black bars between the panels with the disorder scores. Gray shaded area corresponds to the flap regions of PR