Fig. 5. Schematic depictions of the molecular assembly of EphA2 on the cell surface.

(A) Multimeric assembly EphA2 in the absence of ligands. (B) Ligand-induced conformational changes of EphA2, including 71° rotation of the FN2 domain relative to the rest of the Eph ECD. (C) Rearrangement of the kinase domains into close proximity for transphosphorylation on tyrosine residues. (D) Lateral condensation into large EphA2-ephrin higher-order clusters accompanied by activation of canonical signaling and suppression of noncanonical signaling. See text for more details.