Fig. 7a–d.

Both CeMbl-a and CeMbl-b over-expression partially reverse the phenotype of CUG125 and CAG125 worms. The relative CeMbl expression level in double transgenic worms is shown in a. Phenotypes, including b life span, c body bends, and d relative deb-1 RNA level, of worms expressing untranslated CUG125 or CAG125 with or without CeMbl over-expression were compared. At least 30 F3 to F4 generation worms from three independent injections were used for life span and brood size analysis. Three cDNA preparations from one RNA sample combined from several transgenic lines were used for expression analysis of CeMbl and deb-1 genes. Data are given as mean ± SD. Statistical analysis was performed using Student’s t-test. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001