Table 1.
Samples analyzed | De-regulated microRNAs | Trend | Target mRNAs identified | Ref |
---|---|---|---|---|
Human: hippocampus of 5 AD patients, 5 age-matched controls and 5 fetal brains | miR-9, miR-128 | Up | None | [57] |
Human: hippocampus and superior temporal lobe of 23 AD patients and 23 controls | miR-146a | Up | CHF (miR-146a) | [58] |
Human: temporal cortex of 6 AD, 6 MCI patients and 11 controls | miR-107 | Down | BACE1 | [59] |
Human: anterior temporal cortex of 5 AD patients and 5 age-matched controls |
miR-9, -15a, -19b, -22, -26b, -29a/b-1, -93, -101, -106b, -181c, -210, -363, Let7i, |
Down | BACE1 (miR-29a/b-1, -15a, -9, -19b); APP (Let7i, miR-15a, -101, -106b) | [60] |
miR-197, -320, -511 | Up | None | ||
Human: hippocampus of 15 AD patients and 12 controls |
miR-9, -30c, -132, -146b, -210, -212, -425 |
Down | None | [61] |
miR-26a, -27a/b, -30e-5p, -34a, -92, -125b, -145, -200c, -381, -422a, -423 |
Up | None | ||
Human: cerebellum of 15 AD patients and 12 controls | miR-9, -98, -132, -146b, -212, -425 | Down | None | |
miR-27a/b, -34a, -100, -125b, -381, -422a |
Up | None | ||
Human: medial frontal gyrus of 15 AD patients and 12 controls |
miR-9, -26a, -132, -146b, -200c, -212, -425 |
Down | None | |
miR-27a/b, -29a/b, -30c/e-5p, -34a, -92, -100, -125b, -145, -148a, -381, -422a, -423 |
Up | None | ||
Human: CSF from 10 AD patients and 10 controls |
Various—including miR-15b, -142-5p, -146b, -181a |
Down | None | |
Human: white blood cells from 16 AD patients and 16 controls | Various—including miR-34a, -181b, -200a, Let-7f | Up | None | [62] |
Human: anterior temporal cortex of 19 AD patients and 11 controls | miR-106b | Down | APP (miR-106b) | [63] |
Human: temporal lobe cortex of 6 AD, 13 non-AD and 6 controls | miR-9, miR-125b, miR-146a | Up | None | [64] |
Human: parietal lobe cortex of 5 AD patients and 5 controls |
Various—including miR-15a, -20b, -29b/c, -30e-5p, -95, -101, -148b, -181c, -368, -376a, -374, -582 |
Down | None | [65] |
Various—including miR-134, -188, -320, -572, -575, -601, -671, -765 |
Up | None | ||
Human: frontal lobe of 7 AD patients and 4 controls | miR-29a | Down | NAV3 (miR-29a) | [66] |
Human: temporal cerebral cortex–white matter vs. gray matter |
Various—including miR-9, -15a/b, -20a, -21, -30, -106a/b, -107, -29, -30, -34, -128, -181a/b, Let-7i |
Down | None | [135] |
30 miRNAs up-regulated | Up | None | ||
Mouse: cerebral cortex from 3- and 6-month old APPSwe-PS1M146L and WT controls | Various—including miR-22, -29a/b/c, -101a/b, -106b, -125b, -181a | Down | None | [69] |
Various—including miR-28, -34a, -92a/b, -98, -346, Let-7b/c/d/e |
Up | BCL-2 (miR-34a) | ||
Mouse: 4-month old Tg19959 | miR-103, -107 | Down | Cofilin (miR-103, -107) | [142] |
Mouse: primary hippocampal neurons treated with Aβ42 | miR-9, -20b, -21, -148b, -181c, -361, -409, Let-7i | Down | SIRT1, TRIM2, BTBD3, TGFBI | [72, 132] |
miRNAs in bold indicate those repeatedly dysregulated in several studies. mRNAs identified to be regulated by miRNAs (shown in brackets) show either up-regulation (bold italic) or down-regulation (italic) in a subset of AD patients
CHF complement factor H; BACE1 beta-site APP-cleaving enzyme 1; APP amyloid precursor protein; NAV3 neuron navigator 3; SIRT1 sirtuin 1; TRIM2 tripartite motif-containing 2; BTBD3 BTB (POZ) domain containing 3; TGFBI transforming growth factor, beta-induced, 68 kDa