Fig. 9.

Total Mn, Fe, Cu, and Zn content are not critically affected by hAPP presence and MT1 + 2 absence. Prefrontal and total cortical homogenates from 5- and 14-month-old mice (young and old, respectively) were analyzed by ICP-MS. In general, metal content was higher in old females (left) than in males (right), and that despite statistically significant differences were observed, the effects of hAPP and MT1 + 2 deficiency were modest. Results are μg of metal/g of tissue (mean ± SEM; n = 5–8 and 9–12 for young and old mice, respectively), and they were analyzed using GLZ with APP and MT deficiency as main factors. Filled diamond, p < 0.05 versus APP− mice; star, p < 0.05 versus MTWT mice