Table 1.
Transgenic mice models of renal aquaporins
| AQPs | Renal phenotype | References |
|---|---|---|
| AQP1−/− | Polyuria | [77, 142] |
| No sensitivity to vasopressin treatment | ||
| AQP2−/− | Polyuria | [82, 114, 121, 153, 157] |
| Papillary atrophy and hydronephrosis | ||
| AQP3−/− | Severe polyuria | [73, 75] |
| Mild responsivity under vasopressin stimulation or water deprivation | ||
| AQP4−/− | Mild polyuria | [76] |
| AQP7−/− | Mild polyuria | [120] |
| Glyceroluria | ||
| AQP8−/− | No phenotype | [155] |
| AQP11−/− | Kidney polycystic | [86] |
| AQP1−/−/AQP3−/− | Severe polyuria and hydronephrosis | [154] |
| AQP1−/−/AQP4−/− | Severe polyuria | [140] |
| AQP1−/−/AQP7−/− | Severe polyuria | [120] |
| AQP1−/−/AQP8−/− | Polyuria | [155] |
| AQP3−/−/AQP4−/− | Severe polyuria | [73, 75] |
AQP Aquaporin