Table 1.

Information of TRAPP subunits, biochemical functions, and their interacting proteins

TRAPP subunits (yeast/mammals)	Biochemical functions	Interacting proteins identified and other notes
Trs20/TRAPPC2 Homolog: TRAPPC2L or Tca 17 TRAPPC2.19	Part of TRAPPI, not required for Ypt1p/Rab1 GEF activity [4, 10] As adapter for TRAPPC8 or TRAPPC9 for TRAPPIII or TRAPPII assembly, respectively [12]	Intracellular chloride channel proteins CLIC1, CLIC2 [92] Nuclear protein PAM14 [90] Transcription factors MBP1, PITX1, SF1 [91]
Trs23/TRAPPC4	Part of TRAPP1, interacts extensively with Ypt1p/Rab1 to catalyze nucleotide exchange [4, 10]	Syndecan-2 [88] ERK1/2; TRAPPC4 modulates ERK1/2 nuclear localization
Trs31/TRAPPC5	Part of TRAPPI	–
Trs33/TRAPPC6 Homolog: TRAPPC6a, C6b	Part of TRAPPI	–
Bet3/TRAPPC3 Homolog: TRAPPC3L	Part of TRAPPI	Auto-acylate at cystein 68 [83]
Bet5/TRAPPC1	Part of TRAPPI	–
Trs120/TRAPPC9	Part of TRAPPII Intra-Golgi and endosome-to-Golgi traffic TRAPPC9 links TRAPPC10 to TRAPPCII in mammalian cells [12] Potentiate NF-κB transactivation Binds to p150Glued Binds to γ-COP	NF-κB signaling pathway molecules NIK, IKK [78] Dynactin subunit p150Glued [56] Rabin8 [42] COPI coat subunit γ-COP [17]
Trs130/TRAPPC10	Part of TRAPPII Intra-Golgi and endosome-to-Golgi traffic	COPI coat subunit γ-COP [17] Och 1 transcription is activated by Trs130 deletion [87] Genetic interaction with Arf1 and Ypt31 [86]
Trs65/C5orf44	Part of TRAPPII, required for dimerization of two sets of TRAPP in yeast	Gea2 [85]
Trs85/TRAPPC8	Part of TRAPPIII Play a role in autophagy ER-to-Golgi traffic in mammalian cells	–
TRAPPC11 (C40rf41)	Part of mammalian TRAPP	–
TRAPPC12 (a.k.a. TTC-15, CGI-87)	Part of mammalian TRAPP	Binds to TECPR-1 in autophagy network proteomic study [22]