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Management of H3 and H4 during DNA replication. Parental H3/H4 tetramers are displaced ahead of the advancing replicative helicase and are redeposited on the double strand DNA emerging from the polymerases on either leading or lagging strands. Newly synthesised H3/H4 dimers are shown binding first to ASF1 before being handed over to CAF1 bound to PCNA. The stoichiometry of CAF1 at the fork is unclear, but here two CAF1 molecules are shown chaperoning one new dimer each
