Fig. 1.

Schematic representation of FcεRI-mediated intracellular signaling events in mast cells and basophils. The allergen cross linking of FcεRI receptors initiate key cellular signaling events such as the activation of PLCγ, PKCs, SPHKs, PI3Ks, etc. An important role for these major pathways in immune cell function is predicted based on their ability to regulate the transcriptional activity of cytokine genes, calcium release from the internal stores which is essential for the degranulation and further intracellular mediation of signaling processes, and the production of lipid mediators such as prostaglandins and leukotrienes. The specific blocking of these key intracellular signaling molecules such as PLCγ, PKCs, SPHKs, S1P, PI3Ks, etc., by specific chemical inhibitors or siRNAs, or therapeutic Intrabodies would certainly be of immense use in the effective management of allergy and anaphylaxis in the near future